Recurrence is common if the incision is not wide enough to remove all tumor cells. Treatment is most successful when the tumors are discovered early and surgically removed with a very wide incision. A veterinary task force has been formed to research the issue. The prevalence of this problem has not been established, but it may be anywhere between 1:1,000 or 1:10,000 vaccinated cats. It usually appears from 3 months to 4 years after vaccination. They occur most often with the use of killed, adjuvant vaccines- notably rabies and FeLV. Sarcomas are aggressive, locally invasive tumors that seem to form at the site of vaccination in cats. The debate about the safety of vaccines took the forefront in small animal medicine when a possible link was discovered between vaccination and the development of a form of cancer known as sarcomas. Treatment with painkillers, fluids and antibiotics is usually effective. Kittens vaccinated against calici virus may develop a fever and limping approximately 1 week after vaccination. Kittens are borne with a problem called cerebellar hypoplasia, which results in an inability to maintain balance. This is most commonly seen with the use of the panleuopenia (distemper) vaccine in cats. Prenatal infections, fetal malformations, infertility and abortion can result from the use of modified live vaccines in pregnant animals. It appears that these vaccines actually caused disease symptoms. Nervous system problems have been seen after vaccination with modified live rabies (no longer available) and canine distemper vaccines. They usually appear within 1-2 days of vaccination and then disappear. Systemic reactions include fever, depression, loss of appetite, lethargy and weakness. Animals with local reactions should be treated symptomatically, observed carefully and reported to the veterinarian if they persist. These symptoms can occur within minutes to 1 week after vaccination but usually resolve on their own. Granulomas, or hard tissue formations may occur at the site of vaccination. Local reactions include pain, swelling, abscesses, redness and irritation. It can be life threatening and require lifelong therapy, including fluids, steroids, blood transfusions, etc. There can be many causes of AIHA, but vaccination seems to trigger antibody production against red blood cells, resulting in a variety of signs including weakness, lethargy, loss of appetite, exercise intolerance, difficult breathing, increased heart rate, vomiting, diarrhea. To further minimize the risk, avoid using vaccines with multiple antigens, use modified live instead of killed vaccines, make certain the vaccine is not injected into the vein, and use subcutaneous or intranasal vaccines instead of intramuscular ones if possible.Īutoimmune hemolytic anemia (AIHA) has been reported in dogs vaccinated with modified live multiple antigen vaccines, particularly parvo. Treatment consists of administration of epinephrine, antihistamines and supportive care.Īnimals that have had anaphylactic reactions should be treated beforehand with antihistamines if vaccination is mandatory. The signs may be facial swelling, itching, weakness, diarrhea, difficulty breathing, shock and death. Although not very common, the clinical signs can range from mild symptoms to life threatening emergencies. Vaccines that seem to be most likely to cause reactions include the killed rabies, canine corona, FeLV, and Leptospira vaccine. It is virtually impossible to predict that an animal is allergic unless a previous reaction has been noted. Killed vaccines commonly are adjuvanted) They may occur after the 2nd or 3rd vaccination in the booster series, or on initial vaccination. Anaphylaxis can occur after any vaccine is administered, but have been most commonly seen with vaccines that have large amounts of foreign proteins, are adjuvanted (Adjuvants are chemicals that are added to enhance the immune response. Anaphylactic (or allergic) reactions are amongst the most severe reactions that can be seen after vaccination.
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